Synthesis and Design of Novel Oxazolidinone Rings and Evaluation of Their Biological Activity

Mohammed Khalaf Mohammed  Khalaf

doi:10.51699/cajotas.v7i4.1750

Authors

Mohammed Khalaf Mohammed Khalaf Tikrit University, College of Basic Education, Al-Sharqat

DOI:

https://doi.org/10.51699/cajotas.v7i4.1750

Keywords:

heterocyclic, hydrazone, oxazolidinone, bacterial bioactivity

Abstract

In this study, a new, environmentally friendly, solvent-free technique—which is cost-effective and easy to use—was employed to synthesise a number of compounds containing an oxazolidinone ring, by reacting hydrazone with chloroacetic acid via a fusion reaction without the use of any solvent. Basic organic chemistry analyses (FT-IR, ¹H and ¹³C-NMR) showed a clear disappearance of azomethine, indicating complete consumption of the reactants and confirming the validity of the synthesis. In addition, antimicrobial activity was evaluated against two common bacterial species: Escherichia coli and Staphylococcus aureus. Compared with the antibiotic ampicillin, which was used as a control for inhibition, compound M₂ exhibited the strongest antimicrobial activity against Gram-positive bacterial strains; against Gram-negative bacteria, compound M₁ was more effective than the other compounds, The results showed that inhibition improved with increasing concentration. Based on the above, these compounds show promising potential for future medical applications.

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