Preparation And Evaluation Of Bioactivity And Magnetic Sensitivity Of A Group Of Chelated Nickel Complexes

Ghida Shaker Jubouri

doi:10.51699/cajotas.v7i4.1738

Authors

Ghida Shaker Jubouri Ministry of Education / First Karkh Education Directorate / Iraq

DOI:

https://doi.org/10.51699/cajotas.v7i4.1738

Keywords:

Nickel chelated complexes, Magnetic sensitivity, Schiff bases, Antibacterial activity, Magnetic moment

Abstract

The aim of this study was to prepare a group of chelated nickel divalent complexes with novel Schiff base lycandes derived from the condensation of 2-hydroxy-1-naphthaldehyde with some aliphatic and cyclic amines, with the aim of studying the structural, specral, thermal and magnetic properties of these complexes, as well as evaluating their antibacterial and antifungal bioactivity. The prepared complexes were diagnosed using infrared, ultraviolet-visible techniques, elemental analysis, magnetic measurements and thermal analysis techniques. Weight. The infrared results showed the symmetry of the nickel atom through the nitrogen and oxygen atoms in the lycan, while magnetic measurements confirmed that the nickel complexes possess paramagnetic properties with magnetic moment values ranging from 2.83 to 3.45 bormagneton, which corresponds to the geometric arrangement of tetrahedrals or octahedrals. The results of the bioactivity showed that the prepared complexes had antibacterial activity that exceeded the activity of free lycans, with the lowest inhibitory concentration values ranging from 6.25 to 25 μg/mL for different bacterial species. Statistical analyses revealed statistically significant differences at the significance level of 0.05 in bioefficacy between the different complexes, with the measurement tools stable at the value of Cronbach's alpha coefficient of 0.87. The research concluded that complexity with nickel-ion significantly enhances the bioactivity of Schiff base lions, and that magnetic properties are influenced by the structural structure and geometric arrangement of the complex.

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References

S. A. M. Ibrahim and K. F. Al-Samraei, The Chemistry of Harmonic Complexes: Foundations and Applications, 1st ed. Baghdad, Iraq: Safaa Publishing and Distribution House, 2021.

A. K. Al-Jubouri and W. A. Al-Samaraei, “Preparation and diagnosis of divalent nickel complexes with novel azocyclic azo ligands and study of their biological efficacy,” Journal of Applied Sciences, vol. 22, no. 3, pp. 65–88, 2023.

F. A. Al-Hasnawi and Z. K. Mohammed, “Metallic complexes of naphthaldehyde-derived Schiff bases: Preparation, diagnosis, and biopotency,” Iraqi Journal of Chemistry, vol. 17, no. 2, pp. 110–135, 2023.

M. S. Al-Khafaji and H. J. Al-Obaidi, “Antibacterial and antifungal activity of nickel chelated complexes with thiosimicarbazone ligands,” Journal of Chemical Research, vol. 14, no. 1, pp. 52–78, 2022.

S. J. Al-Rubaie and I. K. Abdul-Hussein, “Effect of complexity on the spectral and magnetic and biodynamic properties of transition metal complexes with bi-tooth Schiff ligands,” Journal of the Faculty of Basic Education, vol. 17, no. 4, pp. 85–110, 2021.

O. F. Al-Zubaidi and M. A. Al-Husseini, “Study of magnetic sensitivity and spectral properties of nickel-copper complexes with heterogeneous Schiff ligands,” Journal of Pure Sciences, vol. 25, no. 2, pp. 74–92, 2022.

H. K. Al-Saadi and Z. T. Al-Kinani, “Biological evaluation of transition metal complexes: Measurement methods and mechanisms,” Journal of Scientific Research, vol. 18, no. 3, pp. 98–120, 2021.

A. K. Al-Shammari and S. M. Abdulrahman, Symmetrical Complexes: From Theoretical Foundations to Vital Applications, 2nd ed. Amman, Jordan: Wael Publishing House, 2021.

N. J. Al-Salihi and M. S. Al-Jubouri, “Nickel complexes with Schiff base ligands: The relationship between structural structure and bioactivity,” Journal of Applied Chemistry, vol. 9, no. 2, pp. 76–102, 2022.

L. H. Al-Taie and S. A. Al-Amidi, “Enhancing the bioactivity of complex organic lions with nickel ions: A comparative study,” Journal of Science and Technology, vol. 12, no. 1, pp. 38–60, 2024.

R. S. Al-Nuaimi and A. W. Zakaria, “Magnetic measurements and their importance in diagnosing metal complexes and determining their geometric arrangement,” Journal of Physics and Chemistry, vol. 8, no. 1, pp. 142–170, 2023.

F. H. Al-Moussawi and A. A. Al-Dulaimi, “Computational and experimental studies on nickel chelation complexes with biological applications,” Journal of Advanced Chemical Research, vol. 6, no. 1, pp. 20–48, 2024.

A. A. Al-Dulaimi and F. H. Al-Moussawi, “Techniques for spectral and magnetic diagnosis of metallurgical complexes,” Journal of Pure Science, vol. 19, no. 3, pp. 88–115, 2023.

M. A. Al-Husseini, O. F. Al-Zubaidi, “Chelet complexes with pharmaceutical applications: A recent review,” Journal of Pharmacy and Chemistry, vol. 10, no. 2, pp. 45–72, 2024.

P. Selvin, D. Rajakumar, and K. Manimaran, “Synthesis, characterization, and biological evaluation of nickel(II) Schiff base complexes: Antimicrobial and DNA-binding studies,” Journal of Molecular Structure, vol. 1275, pp. 1145–1158, 2023.

A. H. Kareem, R. M. Al-Samarrai, and M. N. Tawfiq, “Synthesis, characterization and spectral estimation of nickel(II) and copper(II) complexes and study of their antibacterial activity,” Chemical Review and Letters, vol. 7, pp. 1031–1041, 2024.

H. Behzad, M. F. Ghazvini, and B. Jahromi, “Anionic ligands tune the structure and bioactivity of nickel(II) complexes: Synthesis, characterization, DNA/HSA-binding, anticancer/antibacterial studies,” Journal of Inorganic Biochemistry, vol. 264, p. 112587, 2025.