Synthesis, Characterization and Study of Antibacterial Activity and Laser Efficacy of New Isoxazoline Derivatives
Keywords:
Heterocyclic, Isoxazoline, biological activity, laser.
Abstract
This "study involves the preparation of heterocyclic pentameric rings derived from isoxazoline compounds using chalcones as nuclei by reacting previously prepared chalcones with hydroxylamine hydrochloride using ethanol as solvent. Spectroscopic measurements confirmed the activity of the prepared compounds. Examples include infrared spectroscopy, proton nuclear magnetic resonance (NMR) and quantitative elemental analysis (C.H.N). Physical measurements such as melting point, color and product percentage were also performed. Bioavailability was evaluated using two known antibiotic resistant bacterial isolates (Gram-negative Escherichia coli (Gram-ve) and Gram-positive Staphylococcus aureus (Gram+ve) and compared with controls. The antibiotic comparison reagent (control) was amoxicillin. The stability of the prepared compounds against a helium-neon laser was tested over periods of 15-60 s by shining the laser on the compounds and then observing the color change and melting" point
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References
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A. H. Dalaf, "Synthesis and characterization of some quartet and quinary heterocyclic rings compounds by traditional method and microwave routes method and evaluation of their biological activity," M.Sc. thesis, Tikrit Univ., Tikrit, Iraq, 2018.
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T. Shah and V. Desai, "Synthesis and antibacterial studies of some novel isoxazoline derivatives," J. Serbian Chem. Soc., vol. 72, no. 5, pp. 443–449, 2007.
I. Filali, J. Bouajila, M. Znati, F. Bousejra-El Garah, and H. Ben Jannet, "Synthesis of new isoxazoline derivatives from harmine and evaluation of their anti-Alzheimer, anti-cancer, and anti-inflammatory activities," J. Enzyme Inhib. Med. Chem., vol. 30, no. 3, pp. 371–376, 2015.
A. Phanumartwiwath et al., "Antitubercular and antibacterial activities of isoxazolines derived from natural products: Isoxazolines as inhibitors of Mycobacterium tuberculosis InhA," J. Chem. Res., vol. 45, no. 11–12, pp. 1003–1015, 2021.
R. H. Saleh et al., "Synthesis of some new thiazolidinone compounds derived from Schiff bases compounds and evaluation of their laser and biological efficacy," Ann. Trop. Public Health, vol. 23, no. 7, pp. 1012–1031, 2020.
A. H. Dalaf et al., "Environmentally friendly synthesis, bioactivity evaluation, and multi-faceted characterization of bis (5-((1H-imidazol-4-yl) methyl)-3-phenylimidazolidin-4-one) derivatives," Am. J. Biomed. Pharm., vol. 1, no. 7, pp. 104–114, 2024.
A. M. Sulaima and M. S. Hussein, "Preparation of pyrazoline and isoxazoline rings derived from chalcones and testing their antibacterial activity," J. Educ. Sci. Stud., vol. 3, no. 22, 2023.
B. A. Khairallah, F. M. Muhammad, J. N. Saleh, and M. J. Saleh, "Preparation, characterization, biological activity evaluation, and liquid crystallography study of new diazepine derivatives," World Med. J. Biomed. Sci., vol. 1, no. 7, pp. 65–76, 2024.
M. J. Saleh et al., "Preparation and evaluation of the biological activity of a 2-amino pyran ring using a solid base catalyst," Cent. Asian J. Med. Nat. Sci., vol. 5, no. 4, pp. 130–138, 2024.
A. W. A. S. Talluh, M. J. Saleh, and J. N. Saleh, "Preparation, characterisation, and study of the molecular docking of some derivatives of the tetrazole ring and evaluation of their biological activity," World Med. J. Biomed. Sci., vol. 1, no. 7, pp. 15–23, 2024.
A. W. A. S. Talluh, M. J. Saleh, and J. N. Saleh, "Preparation, characterization, and evaluation of biological activity and study of molecular docking of some new thiazolidine derivatives," unpublished.
A. W. A. S. Talluh et al., "Preparation, characterization, and evaluation of the biological activity of new 2,3-dihydroquinazoline-4-one derivatives," Eur. J. Mod. Med. Pract., vol. 4, no. 4, pp. 326–332, 2024.
A. W. A. S. Talluh, "Preparation, characterization, evaluation of biological activity, and study of molecular docking of azetidine derivatives," Cent. Asian J. Med. Nat. Sci., vol. 5, no. 1, pp. 608–616, 2024.
M. J. Saleh and K. A. Al-Badrany, "Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation," Cent. Asian J. Med. Nat. Sci., vol. 4, no. 4, pp. 222–230, 2023.
Published
2024-12-30
How to Cite
Raad Faisal , R., Tariq Ibrahim, N., & Hamed Mohammed, M. (2024). Synthesis, Characterization and Study of Antibacterial Activity and Laser Efficacy of New Isoxazoline Derivatives . Central Asian Journal of Theoretical and Applied Science, 5(8), 730-738. Retrieved from https://cajotas.casjournal.org/index.php/CAJOTAS/article/view/1529
Section
Articles
This work is licensed under a Creative Commons Attribution 4.0 International License.
