Synthesis, Characterization, and Validation Of Novel Thiazine Derivatives For Their Biological And Laser Activity
Keywords:
Heterocyclic, Thiazine, Laser, Biological Activity
Abstract
The research involves the use of chalcones as intermediates, the synthesis of new hexagonal rings from thiazine precursors by reacting previously prepared chalcones with thiourea, and minor modifications to the usual working methods to show that they generate these new rings. The activity of the prepared compounds was proven by physical and spectroscopic techniques such as FT-IR and (1H, 13C-NMR) spectroscopy, as well as the determination of melting point and purity and monitoring the progress of the reaction by thin layer chromatography. The TLC was evaluated using two bacterial isolates known to be resistant to antibiotics, namely Gram-negative Escherichia coli (Gram-ve) and Gram-positive Staphylococcus aureus (Gram+ve). They were compared with the antibiotic amoxicillin as a control agent, and the results showed good inhibitory activity against both types of bacteria used, with high efficacy and selectivity. A helium-neon laser (visible laser) was used to evaluate the laser efficiency of some of the synthesized compounds. Each compound was irradiated for four different periods (15, 30, 45, and 60 seconds) and then physically irradiated. The compounds were examined again, and the surface changes of the compounds" were observed.
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References
Al-Mulla, A. (2017). A review: biological importance of heterocyclic compounds. Der Pharma Chemica, 9(13), 141-147.
Qadir, T., Amin, A., Sharma, P. K., Jeelani, I., & Abe, H. (2022). A review on medicinally critical heterocyclic compounds. The Open Medicinal Chemistry Journal, 16(1).
Asif, M., & Imran, M. (2022). Antimicrobial activities of various thiazine based heterocyclic compounds: a mini-review. Mini-Reviews in Organic Chemistry, 19(2), 166-172.
Choudhary, S., Silakari, O., & Singh, P. K. (2018). Key updates on the chemistry and biological roles of thiazine scaffold: a review. Mini Reviews in Medicinal Chemistry, 18(17), 1452-1478.
Chaucer, P., & Sharma, P. K. (2020). Study of thiazines as potential anticancer agents. Plant Arch, 20(2), 3199-3202.
Wiatrak, B., Krzyżak, E., Szczęśniak-Sięga, B., Szandruk-Bender, M., Szeląg, A., & Nowak, B. (2022). Effect of tricyclic 1, 2-thiazine derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells. Pharmacological Reports, 74(5), 890-908.
Dalaf, A. H., Jumaa, F. H., Aftana, M. M., Salih, H. K., & Abd, I. Q. (2022). Synthesis, Characterization, Biological Evaluation, and Assessment of Laser Efficacy for New Derivatives of Tetrazole. In Key Engineering Materials (Vol. 911, pp. 33-39). Trans Tech Publications Ltd.
Dabholkar, V. V., & Parab, S. D. (2011). Synthesis of chalcones, 1, 3-thiazines and 1, 3-pyrimidines derivatives and their biological evaluation for anti-inflammatory, analgesic, and ulcerogenic activity. The Pharm. Res, 5, 127-143.
Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation, and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization, and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
Al-Hadidi, O. A. F., Al-Badrany, K. A., & Al-Bajari, S. A. (2022). Synthesis of some thiazepine compounds from 2-carbboxyaldehyde-5-methyl thiophene and study of their biological activity on infected male rats epileptic. Journal of Education and Scientific Studies, 2(20).
Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 155-168.
Choudhary, S., Silakari, O., & Singh, P. K. (2018). Key updates on the chemistry and biological roles of thiazine scaffold: a review. Mini Reviews in Medicinal Chemistry, 18(17), 1452-1478.
Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
Al-Suhail, R. G. A., & Ali, L. F. (2021). Statistical analysis of COVID-19 pandemic across the provinces of Iraq. Iraqi Journal of Science, 811-824.
Allami, R. H., Suleiman, A. A., Mouhamad, R. S., Abdullah, M. H., Alsudani, M. Y., & Adhiah, A. H. (2022, November). The risk of up normal values of two parameters obesity and vitamin D in incidence of coronavirus disease-19 among Iraqi patients. In AIP Conference Proceedings (Vol. 2394, No. 1). AIP Publishing.
Shannak, Q. A. (2020). Characteristic Studying and Biological Effect of Synthesized Complexes Pd (II) and Hg (II) with Uracil dithiocarbamate and Phosphine’s. Systematic Reviews in Pharmacy, 11(3), 693-701.
Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
Saleh, M. M., Saleh, J. N., Rokan, F. F., & Saleh, M. J. (2024). Synthesis, Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex [Co (2-(benzo [d] thiazol-2-yloxy) acetohydrazide)(H2O)(Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4).
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., & Al-Jubori, H. M. S. (2024). Synthesis and Characterization of Some New Imine Graphene Derivatives and Evaluation of Their Biological Activity. Central Asian Journal of Medical and Natural Science, 5(4), 272-290.
Abdul Wahed, A. S. T. (2024). Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1, 3-Oxazepine-4, 7-Dione Derivatives. Central Asian Journal of Theoretical and Applied Sciences, 5(2), 15-26.
Talluh, A. W. A. S., Najm, R. S., Saleh, M. J., & Saleh, J. N. (2024). Synthesis, Characterization, and Evaluation of the Biological Activity of Novel Oxazepine Compounds Derived From Indole-5-Carboxylic Acid. American Journal of Bioscience and Clinical Integrity, 1(8), 10-19.
Saleh, M. M. Amenah l. Al-Nassiry, Jamil Nadhem Saleh, & Mohammed Jwher Saleh.(2024). Preparation and Diagnosis of New Complexes for Hg (II) With 4-Amino Acetanilide And (Dppp) As A Ligand And Study Of The Bacterial Efficacy And Molecular Docking Of The Prepared Complexes. Central Asian Journal of Theoretical and Applied Science, 5(4), 364-373.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N. (2024). Application of infrared and nuclear magnetic resonance spectra in studying the bacterial efficacy of some oxazepane derivatives derived from hydrazones. Sensors and Machine Learning Applications, 3(3). https://doi.org/10.69534/smla/193913
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). Green Synthesis, Characterization and Bioactivity Evaluation of Bis (5-((1H-Imidazol) Methyl)-3-Phenylimidazolidin) Derivatives. Vital Annex: International Journal of Novel Research in Advanced Sciences (2751-756X), 3(4), 118-128.
Saleh, M. J., Saleh, J. N., Al-Badrany, K., Talluh, A. W. A. S., Shannak, Q. A., & Abdulmajeed, A. Z. (2024). Use of Solid Basic Catalysts in the Preparation of Cyclohexenone Derivatives and Evaluation of Their Bacterial Activity. Vital Annex: International Journal of Novel Research in Advanced Sciences (2751-756X), 3(3), 104-112.
Dalaf, A. H., Saleh, J. N., Saleh, M. J., & Talluh, A. W. A. S. (2024). Environmentally Friendly Synthesis, Bioactivity Evaluation and Multi-Faceted Characterization of Bis (5-((1H-Imidazol-4-yl) Methyl) -3- Phenylimidazolidin -4- One) Derivatives. American Journal of Biomedicine and Pharmacy, 1(7), 104–114.
Saleh, R. H., Rashid, W. M., Dalaf, A. H., Al-Badrany, K. A., & Mohammed, O. A. (2020). Synthesis of some new thiazolidinone compounds derived from schiff bases compounds and evaluation of their laser and biological efficacy. Ann Trop & Public Health, 23(7), 1012-1031.
Qadir, T., Amin, A., Sharma, P. K., Jeelani, I., & Abe, H. (2022). A review on medicinally critical heterocyclic compounds. The Open Medicinal Chemistry Journal, 16(1).
Asif, M., & Imran, M. (2022). Antimicrobial activities of various thiazine based heterocyclic compounds: a mini-review. Mini-Reviews in Organic Chemistry, 19(2), 166-172.
Choudhary, S., Silakari, O., & Singh, P. K. (2018). Key updates on the chemistry and biological roles of thiazine scaffold: a review. Mini Reviews in Medicinal Chemistry, 18(17), 1452-1478.
Chaucer, P., & Sharma, P. K. (2020). Study of thiazines as potential anticancer agents. Plant Arch, 20(2), 3199-3202.
Wiatrak, B., Krzyżak, E., Szczęśniak-Sięga, B., Szandruk-Bender, M., Szeląg, A., & Nowak, B. (2022). Effect of tricyclic 1, 2-thiazine derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells. Pharmacological Reports, 74(5), 890-908.
Dalaf, A. H., Jumaa, F. H., Aftana, M. M., Salih, H. K., & Abd, I. Q. (2022). Synthesis, Characterization, Biological Evaluation, and Assessment of Laser Efficacy for New Derivatives of Tetrazole. In Key Engineering Materials (Vol. 911, pp. 33-39). Trans Tech Publications Ltd.
Dabholkar, V. V., & Parab, S. D. (2011). Synthesis of chalcones, 1, 3-thiazines and 1, 3-pyrimidines derivatives and their biological evaluation for anti-inflammatory, analgesic, and ulcerogenic activity. The Pharm. Res, 5, 127-143.
Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation, and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization, and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
Al-Hadidi, O. A. F., Al-Badrany, K. A., & Al-Bajari, S. A. (2022). Synthesis of some thiazepine compounds from 2-carbboxyaldehyde-5-methyl thiophene and study of their biological activity on infected male rats epileptic. Journal of Education and Scientific Studies, 2(20).
Al-Tufah, M. M., Jasim, S. S., & Al-Badrany, K. A. (2020). Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives. Prof.(Dr) RK Sharma, 20(3), 178.
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 155-168.
Choudhary, S., Silakari, O., & Singh, P. K. (2018). Key updates on the chemistry and biological roles of thiazine scaffold: a review. Mini Reviews in Medicinal Chemistry, 18(17), 1452-1478.
Talluh, A. W. A. S., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization and Evaluation of Biological Activity and Study of Molecular Docking of Some New Thiazoli-dine Derivatives.
Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
Al-Suhail, R. G. A., & Ali, L. F. (2021). Statistical analysis of COVID-19 pandemic across the provinces of Iraq. Iraqi Journal of Science, 811-824.
Allami, R. H., Suleiman, A. A., Mouhamad, R. S., Abdullah, M. H., Alsudani, M. Y., & Adhiah, A. H. (2022, November). The risk of up normal values of two parameters obesity and vitamin D in incidence of coronavirus disease-19 among Iraqi patients. In AIP Conference Proceedings (Vol. 2394, No. 1). AIP Publishing.
Shannak, Q. A. (2020). Characteristic Studying and Biological Effect of Synthesized Complexes Pd (II) and Hg (II) with Uracil dithiocarbamate and Phosphine’s. Systematic Reviews in Pharmacy, 11(3), 693-701.
Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
Mohammed Jwher Saleh, Jamil Nadhem Saleh, Khalid Al-Badrany, Adil Hussein Dalaf, Reem Suhail Najm, & Abdul Wahed Abdul Sattar Talluh. (2024). Preparation And Evaluation Of The Biological Activity Of A 2- Amino Pyran Ring Using A Solid Base Catalyst. Central Asian Journal of Medical and Natural Science, 5(4), 130 - 138.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
Saleh, M. M., Saleh, J. N., Rokan, F. F., & Saleh, M. J. (2024). Synthesis, Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex [Co (2-(benzo [d] thiazol-2-yloxy) acetohydrazide)(H2O)(Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4).
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., & Al-Jubori, H. M. S. (2024). Synthesis and Characterization of Some New Imine Graphene Derivatives and Evaluation of Their Biological Activity. Central Asian Journal of Medical and Natural Science, 5(4), 272-290.
Abdul Wahed, A. S. T. (2024). Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1, 3-Oxazepine-4, 7-Dione Derivatives. Central Asian Journal of Theoretical and Applied Sciences, 5(2), 15-26.
Talluh, A. W. A. S., Najm, R. S., Saleh, M. J., & Saleh, J. N. (2024). Synthesis, Characterization, and Evaluation of the Biological Activity of Novel Oxazepine Compounds Derived From Indole-5-Carboxylic Acid. American Journal of Bioscience and Clinical Integrity, 1(8), 10-19.
Saleh, M. M. Amenah l. Al-Nassiry, Jamil Nadhem Saleh, & Mohammed Jwher Saleh.(2024). Preparation and Diagnosis of New Complexes for Hg (II) With 4-Amino Acetanilide And (Dppp) As A Ligand And Study Of The Bacterial Efficacy And Molecular Docking Of The Prepared Complexes. Central Asian Journal of Theoretical and Applied Science, 5(4), 364-373.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N. (2024). Application of infrared and nuclear magnetic resonance spectra in studying the bacterial efficacy of some oxazepane derivatives derived from hydrazones. Sensors and Machine Learning Applications, 3(3). https://doi.org/10.69534/smla/193913
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). Green Synthesis, Characterization and Bioactivity Evaluation of Bis (5-((1H-Imidazol) Methyl)-3-Phenylimidazolidin) Derivatives. Vital Annex: International Journal of Novel Research in Advanced Sciences (2751-756X), 3(4), 118-128.
Saleh, M. J., Saleh, J. N., Al-Badrany, K., Talluh, A. W. A. S., Shannak, Q. A., & Abdulmajeed, A. Z. (2024). Use of Solid Basic Catalysts in the Preparation of Cyclohexenone Derivatives and Evaluation of Their Bacterial Activity. Vital Annex: International Journal of Novel Research in Advanced Sciences (2751-756X), 3(3), 104-112.
Dalaf, A. H., Saleh, J. N., Saleh, M. J., & Talluh, A. W. A. S. (2024). Environmentally Friendly Synthesis, Bioactivity Evaluation and Multi-Faceted Characterization of Bis (5-((1H-Imidazol-4-yl) Methyl) -3- Phenylimidazolidin -4- One) Derivatives. American Journal of Biomedicine and Pharmacy, 1(7), 104–114.
Saleh, R. H., Rashid, W. M., Dalaf, A. H., Al-Badrany, K. A., & Mohammed, O. A. (2020). Synthesis of some new thiazolidinone compounds derived from schiff bases compounds and evaluation of their laser and biological efficacy. Ann Trop & Public Health, 23(7), 1012-1031.
Published
2024-12-12
How to Cite
Fadhil, E. (2024). Synthesis, Characterization, and Validation Of Novel Thiazine Derivatives For Their Biological And Laser Activity. Central Asian Journal of Theoretical and Applied Science, 5(8), 693-702. Retrieved from https://cajotas.casjournal.org/index.php/CAJOTAS/article/view/1523
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Articles
