Preparation and Diagnosis of New Complexes for Hg (II) With 4-Amino Acetanilide And (Dppp) As A Ligand And Study Of The Bacterial Efficacy And Molecular Docking Of The Prepared Complexes
Keywords:
3-aminoacetanilide, Hg complexes, Molecular Docking, Biological Activity
Abstract
Mercury complexes are increasingly important for antibacterial action, hence novel Hg complexes were created using 3-aminoacetanilide (L) and dppp. The mercury complex has the formula [HgL2]Cl2, whereas phosphine complexes have the formula [HgL2(dppp)]Cl2. The properties of the produced compounds were determined using FTIR, 31P-NMR, and 1H-NMR. Furthermore, this study concludes the evaluation of the biological activity of prepared complexes against two bacterial species, Pseudomonas aeruginosa (gram-positive) and Citrobacer Freundii (gram-negative), using the Agar well method. The prepared complex [HgL2(dppp)]Cl2 showed greater activity against Pseudomonas aeruginosa than Escherichia coli".
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References
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Mir, M. A., Ashraf, M. W., & Andrews, K. (2024, June). Preparation, spectral analysis of a substituted phenyl acetanilide from aniline. In AIP Conference Proceedings (Vol. 3122, No. 1). AIP Publishing.
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Basha, A. A., & Khan, F. (2023, May). Dielectrics relaxation studies of acrylamide and acetanilide with halogenated phenols in benzene. In AIP Conference Proceedings (Vol. 2492, No. 1). AIP Publishing.
Cahn, A., & Hepp, P. (1886). Das antifebrin, ein neues fiebermittel. Centralblatt für Klinische Medizin, 7, 561-564.
Jenkins, S. (2011). Ashford's Dictionary of Industrial Chemicals. Chemical Engineering, 118(5), 8-9.
Lindstrom, P. J., & Mallard, W. G. (2001). Nist chemistry webbook, nist standard reference database number 69. National Institute of Standards and Technology, Gaithersburg. URL http://webbook. nist. gov.
Smajlagić, A., & Srabović, M. Synthesis, Identification and Characterization of N-(4-Aminophenyl) Acetamide Molecule.
Fairbrother, J. E. (1973). Chloral hydrate. In Analytical profiles of drug substances (Vol. 2, pp. 85-143). Academic Press.
Cai, K. Y., & Zhou, Y. M. (2015). Reduction of nitroarenes to aromatic amines with sodium borohydride in the presence of selenium and actived carbon. Bulletin of Chemical Reaction Engineering & Catalysis, 10(3), 275-280.
Onwudiwe, D. C., & Ajibade, P. A. (2011). Synthesis, characterization and thermal studies of Zn (II), Cd (II) and Hg (II) complexes of N-methyl-N-phenyldithiocarbamate: The single crystal structure of [(C6H5)(CH3) NCS2] 4Hg2. International Journal of Molecular Sciences, 12(3), 1964-1978.
El-Gammal, O. A., Rakha, T. H., Metwally, H. M., & El-Reash, G. A. (2014). Synthesis, characterization, DFT and biological studies of isatinpicolinohydrazone and its Zn (II), Cd (II) and Hg (II) complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 127, 144-156.
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 155-168.
Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
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Aftan, M. M., Salih, H. K., & Talloh, A. A. (2021). Synthesis of new mesogenic Schiff bases ether with polar halogen Substituent and study their liquid crystalline properties. Journal of Education and Scientific Studies, 5(17).
Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
م. م قادر عبد الله شناك العيساوي. (2016). تحضير وتشخيص عدد من معقدات ايونات Mn (II), Co (II), Ni (II), Cu (II), Hg (II) مع مزيج من ليكاندات السكارين و حامض الباربيتيوريك و الثايوباربيتيوريك. journal of the college of basic education, 22(96), 147-164.
Dar, S. H., Thirumaran, S., & Selvanayagam, S. (2015). Synthesis, spectral and X-ray structural studies on Hg (II) dithiocarbamate complexes: A new precursor for HgS nanoparticles. Polyhedron, 96, 16-24.
Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
Saleh, M. M., Saleh, J. N., Rokan, F. F., & Saleh, M. J. (2024). Synthesis, Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex [Co (2-(benzo [d] thiazol-2-yloxy) acetohydrazide)(H2O)(Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4).
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
Saleh, M. J., Saleh, J. N., Al-Badrany, K., Dalaf, A. H., Najm, R. S., & Talluh, A. W. A. S. (2024). Preparation And Evaluation Of The Biological Activity Of A 2-Amino Pyran
one Complex With Ni (Ii) Metal Using Al2o3-oh Solid Base Catalyst. European Journal of Modern Medicine and Practice, 4(5), 25-37.
Li, Y., Yang, Y., Qin, Y., & Chen, X. (2014). Synthesis of acetanilide and its crystal structure analysis. Advanced Materials Research, 1070, 89-92.
Maitra, U., & Behera, M. (2018). Synthesis and Characterization of acetanilide and its molecular dockings. Journal of chemical, biological and physical sciences, 8(3), 505-518.
Srinivasan, S. (2021). Synthesis, characterization, and biological evaluation of acetanilide derivatives. Journal of chemistry and chemical sciences, 11(4), 123-130.
Whiffen, D. H., & Wilson, E. B. (1952). Infrared spectra and the structure of acetanilide. Journal of the American Chemical Society, 74(8), 2031-2035.
Islam, M. S., Ferdous, J., Islam, M. R., Rahman, M., & Arman, M. S. (2020). Synthesis, characterization, and evaluation of acetanilide derivatives as antimicrobial agents. Journal of chemistry, 2020.
Li, W., Wu, Z., & Zhou, Y. (2018). Synthesis and anti-inflammatory activities of novel acetanilide derivatives containing thiazole moiety. Chinese Chemical Letters, 29(5), 651-654.
Akhter, N., & Rahman, M. (2020). Synthesis of Acetanilide and Evaluation of its Biological Activity. International Journal of Chemical and Molecular Engineering, 14(7), 89-94.
Zhou, Q., & Wang, Y. (2013). Synthesis of acetanilide derivatives as potential antitubercular agents. Bioorganic & Medicinal Chemistry Letters, 23(7), 2020-2022.
Umehara, K., Yoshimoto, K., & Tsubouchi, R. (1999). The role of acetanilide in the synthesis of aromatic compounds. Journal of organic chemistry, 64(8), 2367-2374.
El-Mahdy, A. (2018). Acetanilide and its derivatives: A comprehensive review. Medicinal Chemistry Research, 27(2), 549-564.
Sultan, S., & Bano, S. (2017). Acetanilide: a versatile building block for the synthesis of biologically active molecules. European Journal of Medicinal Chemistry, 137, 308-327.
Alkhalifa, F. H., & Ahmed, S. M. (2014). Microwave-assisted synthesis of acetanilide derivatives and their biological evaluation. Arabian Journal of Chemistry, 7(1), 107-112.
Yan, Z., & Zheng, C. (2019). Acetanilide-based inhibitors of protein kinase CK2. European Journal of Medicinal Chemistry, 164, 469-480.
Chung, M. K., Baek, S. S., Lee, S. H., Kim, H. M., Choi, K. H., & Han, S. S. (2007). Repeated Dose and Reproductive/Developmental Toxicities of Acetanilide in Rats. Toxicological Research, 23(4), 391-403.
Reeve, W., & Lowe, V. C. (1979). Preparation of acetanilide from nitrobenzene. Journal of Chemical Education, 56(7), 488.
Mir, M. A., Ashraf, M. W., & Andrews, K. (2024, June). Preparation, spectral analysis of a substituted phenyl acetanilide from aniline. In AIP Conference Proceedings (Vol. 3122, No. 1). AIP Publishing.
Rahme, R. (2022). Detection of Impurities in Acetaminophen Intravenous and Oral Formulations Available on the Lebanese Market (Doctoral dissertation, Lebanese American University).
Basha, A. A., & Khan, F. (2023, May). Dielectrics relaxation studies of acrylamide and acetanilide with halogenated phenols in benzene. In AIP Conference Proceedings (Vol. 2492, No. 1). AIP Publishing.
Cahn, A., & Hepp, P. (1886). Das antifebrin, ein neues fiebermittel. Centralblatt für Klinische Medizin, 7, 561-564.
Jenkins, S. (2011). Ashford's Dictionary of Industrial Chemicals. Chemical Engineering, 118(5), 8-9.
Lindstrom, P. J., & Mallard, W. G. (2001). Nist chemistry webbook, nist standard reference database number 69. National Institute of Standards and Technology, Gaithersburg. URL http://webbook. nist. gov.
Smajlagić, A., & Srabović, M. Synthesis, Identification and Characterization of N-(4-Aminophenyl) Acetamide Molecule.
Fairbrother, J. E. (1973). Chloral hydrate. In Analytical profiles of drug substances (Vol. 2, pp. 85-143). Academic Press.
Cai, K. Y., & Zhou, Y. M. (2015). Reduction of nitroarenes to aromatic amines with sodium borohydride in the presence of selenium and actived carbon. Bulletin of Chemical Reaction Engineering & Catalysis, 10(3), 275-280.
Onwudiwe, D. C., & Ajibade, P. A. (2011). Synthesis, characterization and thermal studies of Zn (II), Cd (II) and Hg (II) complexes of N-methyl-N-phenyldithiocarbamate: The single crystal structure of [(C6H5)(CH3) NCS2] 4Hg2. International Journal of Molecular Sciences, 12(3), 1964-1978.
El-Gammal, O. A., Rakha, T. H., Metwally, H. M., & El-Reash, G. A. (2014). Synthesis, characterization, DFT and biological studies of isatinpicolinohydrazone and its Zn (II), Cd (II) and Hg (II) complexes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 127, 144-156.
Dalaf, A. H., Saleh, M. J., & Saleh, J. N. (2024). GREEN SYNTHESIS, CHARACTERIZATION, AND MULTIFACETED EVALUATION OF THIAZOLIDINONE DERIVATIVES: A STUDY ON BIOLOGICAL AND LASER EFFICACY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 155-168.
Talluh, A. W. A. S., Saleh, M. J., & Saleh, J. N. (2024). Preparation, Characterisation and Study of the Molecular Docking of Some Derivatives of the Tetrazole Ring and Evaluation of their Biological Activity. World of Medicine: Journal of Biomedical Sciences, 1(7), 15-23.
Saleh, M. J., Saleh, J. N., & Al-Badrany, K. (2024). PREPARATION, CHARACTERIZATION, AND EVALUATION OF THE BIOLOGICAL ACTIVITY OF PYRAZOLINE DERIVATIVES PREPARED USING A SOLID BASE CATALYST. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(7), 25-32.
Talluh, A. W. A. S., Saleh, M. J., Saleh, J. N., Al-Badrany, K., & mohammed saleh Al-Jubori, H. (2024). Preparation, characterization, and evaluation of the biological activity of new 2, 3-dihydroquinazoline-4-one derivatives. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(4), 326-332.
Abdul Wahed, A. S. T. (2024). Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1, 3-Oxazepine-4, 7-Dione Derivatives. Central Asian Journal of Theoretical and Applied Sciences, 5(2), 15-26.
Aftan, M. M., Salih, H. K., & Talloh, A. A. (2021). Synthesis of new mesogenic Schiff bases ether with polar halogen Substituent and study their liquid crystalline properties. Journal of Education and Scientific Studies, 5(17).
Saleh, J. N., & Khalid, A. (2023). Synthesis, characterization and biological activity evaluation of some new pyrimidine derivatives by solid base catalyst AL2O3-OBa. Central Asian Journal of Medical and Natural Science, 4(4), 231-239.
Khairallah, B. A., Muhammad, F. M., Saleh, J. N., & Saleh, M. J. (2024). Preparation, Characterization, Biological Activity Evaluation, and Liquid Crystallography Study of New Diazepine Derivatives. World of Medicine: Journal of Biomedical Sciences, 1(7), 65-76.
Talluh, A. W. A. S. (2024). Preparation, Characterization, Evaluation of Biological Activity, and Study of Molecular Docking of Azetidine Derivatives. Central Asian Journal of Medical and Natural Science, 5(1), 608-616.
م. م قادر عبد الله شناك العيساوي. (2016). تحضير وتشخيص عدد من معقدات ايونات Mn (II), Co (II), Ni (II), Cu (II), Hg (II) مع مزيج من ليكاندات السكارين و حامض الباربيتيوريك و الثايوباربيتيوريك. journal of the college of basic education, 22(96), 147-164.
Dar, S. H., Thirumaran, S., & Selvanayagam, S. (2015). Synthesis, spectral and X-ray structural studies on Hg (II) dithiocarbamate complexes: A new precursor for HgS nanoparticles. Polyhedron, 96, 16-24.
Saleh, M. J., & Al-Badrany, K. A. (2023). Preparation, characterization of new 2-oxo pyran derivatives by AL2O3-OK solid base catalyst and biological activity evaluation. Central Asian Journal of Medical and Natural Science, 4(4), 222-230.
Saleh, M. M., Saleh, J. N., Rokan, F. F., & Saleh, M. J. (2024). Synthesis, Charactarizit and evaluation of bacterial efficacy and study of molecular substrates of cobalt (II) complex [Co (2-(benzo [d] thiazol-2-yloxy) acetohydrazide)(H2O)(Cl2)]. Central Asian Journal of Medical and Natural Science, 5(4).
Sattar Talluh, A. W. A., Saleh, J. N., Saleh, M. J., & Saleh Al-Jubori, H. M. (2024). Preparation and Characterization of New Imidazole Derivatives Derived From Hydrazones and Study of their Biological and Laser Efficacy. Central Asian Journal of Theoretical and Applied Science, 5(4), 202-211.
Muhammad, F. M., Khairallah, B. A., Saleh, M. J., & Saleh, J. N. (2024). Preparation and Characterization of New Rings of Oxazine Derivatives and Studying Their Biological and Laser Effectiveness and Molecular Docking. Central Asian Journal of Theoretical and Applied Science, 5(4), 190-201.
Saleh, M. J., Saleh, J. N., Al-Badrany, K., Dalaf, A. H., Najm, R. S., & Talluh, A. W. A. S. (2024). Preparation And Evaluation Of The Biological Activity Of A 2-Amino Pyran
one Complex With Ni (Ii) Metal Using Al2o3-oh Solid Base Catalyst. European Journal of Modern Medicine and Practice, 4(5), 25-37.
Li, Y., Yang, Y., Qin, Y., & Chen, X. (2014). Synthesis of acetanilide and its crystal structure analysis. Advanced Materials Research, 1070, 89-92.
Maitra, U., & Behera, M. (2018). Synthesis and Characterization of acetanilide and its molecular dockings. Journal of chemical, biological and physical sciences, 8(3), 505-518.
Srinivasan, S. (2021). Synthesis, characterization, and biological evaluation of acetanilide derivatives. Journal of chemistry and chemical sciences, 11(4), 123-130.
Whiffen, D. H., & Wilson, E. B. (1952). Infrared spectra and the structure of acetanilide. Journal of the American Chemical Society, 74(8), 2031-2035.
Islam, M. S., Ferdous, J., Islam, M. R., Rahman, M., & Arman, M. S. (2020). Synthesis, characterization, and evaluation of acetanilide derivatives as antimicrobial agents. Journal of chemistry, 2020.
Li, W., Wu, Z., & Zhou, Y. (2018). Synthesis and anti-inflammatory activities of novel acetanilide derivatives containing thiazole moiety. Chinese Chemical Letters, 29(5), 651-654.
Akhter, N., & Rahman, M. (2020). Synthesis of Acetanilide and Evaluation of its Biological Activity. International Journal of Chemical and Molecular Engineering, 14(7), 89-94.
Zhou, Q., & Wang, Y. (2013). Synthesis of acetanilide derivatives as potential antitubercular agents. Bioorganic & Medicinal Chemistry Letters, 23(7), 2020-2022.
Umehara, K., Yoshimoto, K., & Tsubouchi, R. (1999). The role of acetanilide in the synthesis of aromatic compounds. Journal of organic chemistry, 64(8), 2367-2374.
El-Mahdy, A. (2018). Acetanilide and its derivatives: A comprehensive review. Medicinal Chemistry Research, 27(2), 549-564.
Sultan, S., & Bano, S. (2017). Acetanilide: a versatile building block for the synthesis of biologically active molecules. European Journal of Medicinal Chemistry, 137, 308-327.
Alkhalifa, F. H., & Ahmed, S. M. (2014). Microwave-assisted synthesis of acetanilide derivatives and their biological evaluation. Arabian Journal of Chemistry, 7(1), 107-112.
Yan, Z., & Zheng, C. (2019). Acetanilide-based inhibitors of protein kinase CK2. European Journal of Medicinal Chemistry, 164, 469-480.
Published
2024-07-28
How to Cite
Mahmood Mahdy Saleh, Amenah l. Al-Nassiry, Jamil Nadhem Saleh, & Mohammed Jwher Saleh. (2024). Preparation and Diagnosis of New Complexes for Hg (II) With 4-Amino Acetanilide And (Dppp) As A Ligand And Study Of The Bacterial Efficacy And Molecular Docking Of The Prepared Complexes. Central Asian Journal of Theoretical and Applied Science, 5(4), 364-373. Retrieved from https://cajotas.casjournal.org/index.php/CAJOTAS/article/view/1488
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